Pharmacokinetics Terminology (04:04)
Explanations include: onset of action, time to peak effect, action duration, half-life, steady state, onset, duration, and peak and trough. A gentamicin example demonstrates the peak and trough concept.
Factors affecting enteral medication bioavailability include: the active and inactive metabolite ratio, gastric acid levels, intestinal motility rate, biorhythms, chemical attributes, drug interactions, bowel alterations, and exercise. Parental medications are 100% available. Learn about IM, subcutaneous, topical, transdermal, and inhalant routes.
Distribution factors include elimination and target organs; monitor for liver and renal toxicity. Drugs may bind to albumin, becoming too big to pass through capillary walls. Learn about conditions with decreased albumin, drug-drug interactions, and water soluble and fat soluble drugs.
Metabolism and Excretion (02:34)
Drugs may be metabolized to inactive metabolites, more soluble compounds, more potent active metabolites, or less active metabolites. Decreased liver function may be a contraindication. Decreased renal function affects elimination and dosing. Pharmacokinetic concepts are important in medication safety and effectivity.
Credits: Pharmacokinetics: What the Body Does to a Drug (00:33)
Credits: Pharmacokinetics: What the Body Does to a Drug
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